In this paper, several domestic and foreign pharmaceutical products crystal filter characteristics of the centrifuges to start, the crystallization of the drugs used in the filter cake layer filter and fixed-side filtering rate in the centrifuge, and adaptability of the economy in areas such as comparing, For medicinal crystal filter centrifuge development, the development and selection provided useful advice and ideas. In the field of centrifugal force to achieve liquid - liquid, liquid - solid, liquid - liquid / solid separation equipment have been born more than a century, the development of the nuclear industry followed by the birth of a gas - gas separation equipment,Field use centrifugal force to achieve physical separation of the branches of a lot of equipment from the suspension to filter out solid-phase liquid-solid material is centrifuge in a branch of the 19th century there have been a variety of crystal filter centrifuge.According to the separation of particles to determine the size of the centrifuge discharge can be divided into: (1) filter cake, layer cake into a fixed intermittent discharge centrifuge (the filter cake referred to as fixed-centrifuge)，If the three-foot artificial discharge, discharge Diaodai centrifuges, scraper discharge centrifuge, centrifuge bag over, and so on; (2) filter cake, layer cake into a mobile discharge centrifuge in a row, such as horizontal pulse Discharge, discharge screw, moving Britain discharge, discharge vibration, centrifugal force centrifuge discharge, and so on.The pharmaceutical industry in the crystal (or amorphous solid-phase) filter widely used in the filter cake layer fixed centrifuges, the machines, equipment common to have emerged in the chemical industry, light industry, food, pharmaceutical production, and so on are available.The 1990 introduction of foreign drugs for production of centrifugal filter, in general based on the modified model, in line with the GMP used in aseptic technique, such as KraussMaffei the HZ-ph series, Ferrum of the HSZ-ph series, Heinkel's HF series, Okawara of the CRF family, as well as Fima; Comi / Condor companies such as the production of various forms of medicinal centrifugal filter.1 filter cake under pressure from the theoretical basis for the current domestic as well as the introduction of foreign technology or the introduction of generic pharmaceutical centrifugal filter separation of its operations are carried out to filter cake, it is designed to build pressure on the state of filter cake on the basis of the theory, Under pressure cake filtration rate equation (layer cake with liquid flow for the current stagnation <1m / s =:…………………(1) where: V-filter in the θ amount of liquid escaped after the time; A-filtering area; θ-time filtering; Rc-filtering units of the cake resistance area; Rm-unit filter area of resistance medium filters; -- Pressure filter; μ-viscosity liquid; the 1950s JAStorrow and others in the pressure filter based on the basic equation centrifuge cake filtration rate equation: ... ... ... ... ... ... ... (2) where: ρc-liquid Relative density; ω-angular velocity; k-penetration inherent in the cake; h-effective rotor length H. Grace included in the cake resistance, porosity and other factors in the above is given on the basis of the rate equation:…………………(3) where: α-cake resistance; W-Solid cake of the total mass of particles; W = πhρs (1-ε) (r32-r22); ρs-density solid-state; ε-type void (2) (3) is still a fixed filter cake layer filter centrifuge theory of one of the basic equation. 2 foreign fixed-layer cake filtration centrifuges abroad, the characteristics of filter cake to launch fixed-centrifuge reason why there are different models, mainly determined by way of discharging：(1) Artificial discharge, as the hanging-foot-three, and so on, this type of centrifuge in widespread use in pharmaceutical production, with industrial development has been a considerable part of the automatic discharge of alternative models; (2) automatic discharge, Drugs recommended as the crystallization of the filter cake layer filter fixed on behalf of the centrifuge models have a horizontal blade discharge centrifuge, double bag filter centrifuges and centrifuge and one dry bed of gas centrifuges and other discharge. They briefed the features: 2.1 scraper blade discharge centrifuge discharge centrifuge, with wide use of the rotor blade to a certain point of rotation within a removable solid-state, medicinal scraper centrifuge closed for the whole structure, with automatic control system, the remnants of filter Cake removal installation shown in Figure 5, office cleaning and office automatic disinfection device as shown in Figure 6, according to the need to be installed through walls (part of the operation and process-driven part of the installation of isolation, to achieve pollution-free and aseptic). There are shortcomings: As the discharge decision by the way, scrape in damage when discharging solid-state crystal, fine particles of solid-state centrifugal force field in the form of hard when the cake is difficult to achieve a more thorough discharge, in particular deposition At both ends of the rotor surface layer cake. 2.2 over centrifuges Bag over centrifuges Bag, part of the work by the hole and the rotor can be reversed with a bag inside the rotor, when the discharge within the rotor to launch cake at the same time turned a removable filter bag to complete the cake As shown in Figure 7. It's features: the complete discharge does not undermine the solid crystal, in the feed tube between the rotor and an additional gas-tight device can be pressurized filter (≤ 6ban), configure the heat outside the circulatory system can be realized within the rotor in solid-state dry. However, the existence of filter media (bags) as a result of fatigue and flipped over and over again, the impact on the life and the pollution caused by solid-phase. Another trip is expected to push its effective rotor length of 2 times, a little structure and the use of large low-speed removable solid equal to address the stability of the equipment. 2.3 centrifugal filter discharge gas-centrifuge and filter into the dry bed gas discharge centrifugal filter, this model in the machine carried out dry, reduce the flow of a link, but have to filter the suspension of Nature of the requirements of a certain limitations.As a result of today's drying equipment in the clean, efficient, energy-saving in areas such as a lot improve the development and use one machine and dry filtration Selection filter, dry sub-modular equipment economy (including the cost of equipment and use of cost) to be explored. Another need: in particular the conditions under which the superiority. 3 centrifugal filter next to the filter and analysis of the characteristics of the end of the 20th century in China for drug crystal products (including amorphous solid-phase) has developed a theory, no filter cake next to the filter filter centrifugal filter (referred to as PL under the centrifuge, which At that time, intended to replace the widely used drug in the three-foot centrifuge, hanging on the type of centrifuge, and so on and achieve automation equipment. 3.1 centrifugal filter next to the principle of PL filter centrifuges working principle: suspension into the rotor After the centrifugal force in the field at the same time liquid and solid-state settlement without a cake from the side of the filter medium escape, the realization of liquid / solid separation. Rotor in solid-state within Shuaigan in turn pushed by the state is expected to launch devices in Figure 9 indicated. 3.2 centrifugal filter next to the filter filtration rate and adaptability materials for the analysis of the PL 2 centrifuges working principle determines the PL in centrifuges to filter and rate adaptation of materials, the two major indicators are better than filter Filter cake layer fixed centrifuges, the analysis of these two indicators are as follows: 3.2.1 filtration rate and fixed-centrifuge filter cake compared to L set a one-time feed for centrifuges, according to the centrifugal force in the field are given under pressure PL centrifuge filtration rate equation: p4) where: Z-filter media (r5-r2) h area of the number of both rate than when η = 1 on both the same rate, the style becomes: 5) Determination of filter media for the nylon or cotton cloth when Rm = 10-9m-1, as a result of a relatively small Rm To simplify the comparison, with a little of Rm negligible on-written: ... ... ... ... ... ... ... (6) When the PL Centrifuges actual filter media area for the number of Z1 when: Z1 = Z, PL centrifuge and filter cake layer fixed rate equal to the centrifuge; Z1> Z, PL centrifuge cake filtration rate than fixed-rate centrifuge;PL centrifuge cake filtration rate of less than fixed-rate centrifuges. According to the value of the Z1, and other factors that determine the structure to allow the. PL has Centrifuge Z1p production value, calculated Zp η value and the value of such a table, not the production design of the layout of the Z1, the calculation of the value of Z and η value, such as Table 2. Η from the table to see the value in the one-time feeding conditions, PL escape centrifuges at a rate of liquid in the filter cake layer fixed rate of 120% or more centrifuges, continuous feed conditions η its value even higher, the practice PL650 as an example to prove that up to 200%. Table 1 centrifuges PL health products Z1, Z, h value models Z1p Zpη PL 4001814.561.23 PL 6502417.671.36 Table 2 models Z1p Zpη P 10002419.851.20 P 12502815.851.76.
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